Table 3.
Predicted causal networks explaining observed gene expression differences based on combined HER3-EGFR protein expression.
| Master Regulator | Log2FC | Participating regulators | Predicted Activation State | Activation z-score | p-value of overlap | corrected p-value |
|---|---|---|---|---|---|---|
| TXN | −1.93 | Ap1, CASP3, CASP8, EGFR, GAPDH, HIF1A, MAPK14, MAPK8, NFkB (complex), NFKB1, NFKBIA, P38 MAPK, PARP1, SMAD3, TP53, TXN | Inhibited | −2.18 | 1.64E-02 | 8.80E-03 |
| RTN1 | 2.05 | BCL2L1, BID, CASP3, CASP8, F3, GSK3B, ITPR1, Jnk, Mapk, MAPK8, NFkB (complex), P38 MAPK, Pdi, RTN1, TERT, TP53, UGCG | Activated | 2.54 | 1.77E-02 | 8.50E-03 |
| TPSD1 | −1.33 | MAPK1, MAPK14, MAPK3, MAPK8, MAPK9, RARRES2, TPSD1 | Inhibited | −2.11 | 1.82E-02 | 6.50E-03 |
| HDAC1 | −1.28 | AR, E2F3, E2F4, EGFR, HDAC1, KDM1A, LEF1, PPARG, RB1, Smad2/3-Smad4, SMAD7, TP53 | Activated | 3.28 | 3.56E-02 | 2.73E-02 |