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. 2020 Feb 20;10:3078. doi: 10.1038/s41598-020-59743-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bone microstructure of type 2 diabetes osteoporosis mice. C57BKS db/db mice were included in the db/db group (n = 15), and their lean littermates C57BKS mice were included in the WT group (n = 15). (A) The body weight and FBG levels in the db/db group were significantly higher than those in the WT group at 12 weeks of age, while the ISI levels were consistently lower in the db/db group than in the WT group. (B) Micro-CT scanning at 12 weeks. The BMD, BV/TV, Tb.N and Tb. Th values in the db/db group were significantly lower than those in the WT group. (C) HE staining at 12 weeks. The number and thickness of trabecular bone were significantly lower in the db/db group than those in the WT group. HE staining data are expressed as the fold induction relative to the control. Values are presented as the mean ± SD. *P < 0.05 vs. WT, n = 15 per group.