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. 2020 Feb 20;10:3078. doi: 10.1038/s41598-020-59743-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of NIPA2 on osteogenic capability. (A) Western blot showing OPG, OCN, Runx-2 and Collagen-I protein levels in transfected hFOB1.19 cells after HG treatment for 72 h. (B) Activity of ALP in transfected hFOB1.19 cells after HG treatment for 72 h. (C) Alizarin red S staining assay showing the mineralized extracellular matrix of transfected hFOB1.19 cells after osteogenic differentiation for 14 days. Values are presented as the mean ± SD of three independent experiments. *P < 0.05 vs. HG, ^#P < 0.05 vs. HG + LV-NIPA2. Data are expressed as the fold induction relative to HG.