Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 20;10:3078. doi: 10.1038/s41598-020-59743-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The mitophagy of hFOB1.19 cells regulated by NIPA2 was mediated via the PGC-1α/FoxO3a signaling pathway. (A) Western blot showing PGC-1α, p-FoxO3a and FoxO3a protein levels in NIPA2-transfected hFOB1.19 cells after HG treatment for 72 h. *P < 0.05 vs. HG. Data are expressed as the fold induction relative to HG. (B) Western blot showing PGC-1α, p-FoxO3a, FoxO3a, P62, OPG, OCN, Runx-2, Collagen-I and mitochondrial PINK1, Parkin, and LC3 protein levels in NIPA2-overexpressing hFOB1.19 cells after 10 μM SR-18292 treatment in HG for 72 h. (C) Activity of ALP in NIPA2-overexpressing hFOB1.19 cells after 10 μM SR-18292 treatment in HG for 72 h. *P < 0.05 vs. HG + LV-Ctrl, ^#P < 0.05 vs. HG + LV-NIPA2. Data are expressed as the fold induction relative to HG + LV-Ctrl. Values are presented as the mean ± SD of three independent experiments.