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. 2020 Feb 20;10:3061. doi: 10.1038/s41598-020-59898-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fth1^−/− macrophages have decreased production of nitric oxide but normal release of TNFa as compared to Fth1^+/+ macrophages. Fth1^+/+ (black) and Fth1^−/− (grey) BMDM were treated with IFNG plus LPS, for 3 days. (a) Nitrite production was quantified in the supernatant by the Griess assay. (b) The release of TNFa from BMDM was measured by ELISA. The results shown represent the mean + SD of two to six independent cultures per group (two-way ANOVA with Tukey multiple comparisons test; *p < 0.05).