Table 3.
Alterations in gene expression ain Fth1+/+ and Fth1−/− BMDM upon FAC or hemin treatments, at 12 h.
| Genes of interest | BMDM genotype | FAC | Hemin |
|---|---|---|---|
| Fth1 | Fth1+/+ | 1.65 ± 0.83 | 2.94 ± 1.26 |
| Fth1−/− | 0.11 ± 0.05* | 0.10 ± 0.03* | |
| Ftl | Fth1+/+ | 3.38 ± 2.60 | 3.57 ± 0.16 |
| Fth1−/− | 4.61 ± 2.39 | 5.10 ± 0.27 | |
| Slc40a1 | Fth1+/+ | 3.92 ± 2.30 | 18.19 ± 0.27 |
| Fth1−/− | 11.53 ± 0.25 | 18.65 ± 14.23 | |
| Tfrc | Fth1+/+ | 1.39 ± 0.73 | 0.31 ± 0.14 |
| Fth1−/− | 1.0. ± 0.60 | 0.30 ± 0.32 | |
| Hmox1 | Fth1+/+ | 6.09 ± 6.70 | 20.19 ± 7.54 |
| Fth1−/− | 10.24 ± 9.00 | 17.07 ± 9.34 | |
| Sod2 | Fth1+/+ | 4.05 ± 2.45 | 4.65 ± 1.47 |
| Fth1−/− | 4.40 ± 2.08 | 5.06 ± 2.75 | |
| Cat | Fth1+/+ | 7.36 ± 5.31 | 11.57 ± 1.87 |
| Fth1−/− | 14.22 ± 0.42 | 17.85 ± 3.69 | |
| Trxr | Fth1+/+ | 6.34 ± 5.58 | 16.33 ± 8.17 |
| Fth1−/− | 6.16 ± 3.24 | 11.50 ± 1.98 | |
| Gclc | Fth1+/+ | 1.68 ± 0.71 | 12.11 ± 7.23 |
| Fth1−/− | 2.48 ± 0.18 | 3.64 ± 1.66 |
aThe values are calculated as the fold change relative to the Fth1+/+ non-treated cells, and represent the mean ± SD of three independent cultures per condition; two-way ANOVA *p < 0.05.