Table 1.
Subjects’ characteristics at baseline
| Parameter | Ze 450 (N = 32) | MHT (N = 142) | p value | ||
|---|---|---|---|---|---|
| n | Median [lq, uq] or n (%) | n | Median [lq, uq] or n (%) | ||
| Age (years) | 32 | 53.0 [48.5, 55.0] | 142 | 52.0 [47.0, 55.0] | 0.93 |
| Body mass index (kg/m2) | 31 | 24.5 [22.7, 27.4] | 136 | 24.1 [21.2, 28.6] | 0.68 |
| Waist circumference (cm) | 26 | 85.0 [79.0, 102.0] | 122 | 88.0 [79.0, 96.0] | 0.79 |
| Systolic blood pressure (mmHg) | 31 | 120 [112, 135] | 138 | 120 [112, 130] | 0.50 |
| Diastolic blood pressure (mmHg) | 31 | 80.0 [75.0, 88.0] | 138 | 80.0 [70.0, 84.0] | 0.13 |
| Age at menarche (years) | 31 | 14.0 [13.0, 15.0] | 134 | 13.0 [12.0, 15.0] | 0.16 |
| Cycle length (days) | 9 | 28.0 [28.0, 29.0] | 24 | 28.0 [26.5, 28.0] | 0.36 |
| Age at menopause (years) | 18 | 49.5 [45.0, 53.0] | 67 | 48.0 [42.0, 51.0] | 0.14 |
| Time since last menstruation (years) | 29 | 2.40 [0.47, 10.54] | 124 | 2.42 [0.28, 8.44] | 0.75 |
| Reproductive stage according to STRAW + 10 [15] | 29 | 121 | 0.038 | ||
| Premenopause | 1 (3%) | 21 (17%) | |||
| Early menopausal transition | 2 (7%) | 23 (19%) | |||
| Late menopausal transition | 2 (7%) | 11 (9%) | |||
| Postmenopause | 24 (83%) | 66 (55%) | |||
| Smoking | 32 | 142 | 0.09 | ||
| Never | 18 (56%) | 102 (72%) | |||
| Currently | 8 (25%) | 30 (21%) | |||
| In the past | 6 (19%) | 10 (7%) | |||
| Alcohol | 32 | 142 | 0.67 | ||
| Never | 16 (50%) | 59 (42%) | |||
| Regularly | 6 (19%) | 27 (19%) | |||
| From time to time | 10 (31%) | 56 (39%) | |||
| AGLA® 10-year risk for fatal and non-fatal coronary heart disease (%) | 21 | 0.70 [0.50, 1.20] | 89 | 0.40 [0.20, 1.20] | 0.12 |
| FRAX® 10-year risk for osteoporotic fractures (%) | 29 | 5.70 [4.40, 7.00] | 127 | 5.60 [4.10, 7.10] | 0.68 |
| GAIL® 5-year risk for breast cancer (%) | 31 | 1.30 [1.20, 1.50] | 137 | 1.40 [1.10, 1.90] | 0.22 |
N total number of observations, n number of non-missing observations