Table 4.

Change of body weight, metabolic parameters and menopausal symptoms over time after adjustment for baseline covariates (diastolic blood pressure, age at menarche, reproductive stage, smoking status, MRS-II vegetative subscore, and MRS-II psychological subscore)

	N observations/patients	Ze 450		MHT		Difference (Ze 450−MHT)
		Change per year (95% CI)	p value	Change per year (95% CI)	p value	Per year (95% CI)	p value
Body weight (kg)	180/126	− 0.21 (− 1.23, 0.81)	0.69	0.35 (− 0.10, 0.79)	0.13	− 0.55 (− 1.67, 0.56)	0.33
Fasting glucose (mmol/l)	153/106	0.04 (− 0.18, 0.26)	0.72	− 0.00 (− 0.09, 0.09)	0.97	0.04 (− 0.19, 0.28)	0.73
Fasting insulin (mU/l)	105/85	1.12 (− 0.95, 3.20)	0.29	− 0.53 (− 1.37, 0.31)	0.21	1.66 (− 0.58, 3.89)	0.15
HOMA index	99/82	0.33 (− 0.24, 0.89)	0.26	− 0.13 (− 0.36, 0.10)	0.26	0.46 (− 0.15, 1.07)	0.14
Total cholesterol (mmol/l)	169/112	0.09 (− 0.04, 0.22)	0.17	0.00 (− 0.06, 0.07)	0.89	0.09 (− 0.06, 0.24)	0.25
HDL-cholesterol (mmol/l)	169/112	− 0.01 (− 0.08, 0.07)	0.84	− 0.00 (− 0.04, 0.04)	0.89	− 0.00 (− 0.09, 0.08)	0.91
LDL-cholesterol (mmol/l)	168/113	0.06 (− 0.07, 0.20)	0.34	− 0.01 (− 0.08, 0.05)	0.70	0.08 (− 0.07, 0.22)	0.30
Triglyceride (mmol/l)	169/112	0.01 (− 0.11, 0.13)	0.87	0.00 (− 0.06, 0.07)	0.94	0.01 (− 0.13, 0.15)	0.91
MRS-II Total score	231/126	− 1.82 (− 3.65, 0.02)	0.05	− 0.87 (− 1.26, − 0.48)	<  0.0001	− 0.94 (− 2.82, 0.93)	0.32
MRS-II vegetative score	231/126	− 0.69 (− 1.50, 0.12)	0.10	− 0.16 (− 0.33, 0.01)	0.07	− 0.53 (− 1.36, 0.29)	0.21
MRS-II psychological score	231/126	− 0.14 (− 1.00, 0.72)	0.75	− 0.42 (− 0.60, − 0.24)	< 0.0001	0.28 (− 0.59, 1.16)	0.52
MRS-II urogenital score	231/126	− 0.79 (− 1.60, 0.02)	0.05	− 0.24 (− 0.42, − 0.07)	0.005	− 0.55 (− 1.37, 0.28)	0.19

Only the effects of MHT and Ze 450 are shown