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. 2020 Feb 20;10:3017. doi: 10.1038/s41598-020-59929-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-course of the analgesic properties of LIT-001 on CFA-induced inflammatory pain model. (a) Scheme of the CFA-induced inflammatory pain model followed by i.p. LIT-001 injection. (b) Left, time-course of the effects of i.p. LIT-001 10 mg/kg (n = 8), its vehicule (n = 7) or co-injection with L-368,699 (n = 7), on CFA-induced edema size (CFA, n = 14; NaCl, n = 18). Right, relative-to-baseline AUC (%) of the effects. (c) Left, time-course of the effects of i.p. LIT-001 10 mg/kg (n = 7), its vehicule (n = 8) or co-injection with L-368,699 (n = 6) on CFA-induced mechanical (c1) and thermal heat (c2) hyperalgesia. Right, relative-to-baseline AUC (%) of the effects. (d) Left, time-course of the effects of i.p. LIT-001 10 mg/kg (n = 7), its vehicule (n = 8) or co-injection with L-368,699 (n = 6) on mechanical (d1) and thermal heat (d2) sensitivities of NaCl-injected hindpaw. Right, relative-to-baseline AUC (%) of the effects. Data are expressed as mean ± SEM. Asterisks indicate statistical significance (***p < 0.001; **p < 0.01; *p < 0.05) using two-way ANOVA followed by Tukey’s multiple comparisons test.