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. 2020 Feb 20;10:3017. doi: 10.1038/s41598-020-59929-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LIT-001 distribution and clearance in the organism. (a) Scheme displaying the i.p. injection of LIT-001, 10 mg/kg in naïve animal. (b) Time course of the concentrations of LIT-001 present in the plasma of rats after an i.p. injection. (c) Concentrations of LIT-001 present at 60 and 300 min after i.p. injection, in the brain (60, n = 6; 300, n = 5), CSF (60, n = 4; 300, n = 4), plasma (60, n = 11; 300, n = 5) and urine (60, n = 6; 300, n = 5) 60 min and 300 min after i.p. injection. Data are expressed as mean ± SEM. Data are expressed as mean ± SEM of 5 animals.