Supplemental Table I.
Summary of previous therapies used in erythema dyschromicum perstans
| Year, Study | Study type | no, Sex | Age range (yr) | Ethnicity | Therapies used | Reported treatment outcomes |
|---|---|---|---|---|---|---|
| 2018,S1 | Retrospective study | 26, NA | 16-65 | Asian | Topicals: steroid, hydroquinone, tacrolimus, tretinoin; oral steroid | Five showed improvement following combined topical hydroquinone and steroid; remaining showed stable disease at 0.5- to 3-mo follow-up |
| 2018,S2 | Case report | 1 Male | 17 | NA | Narrow-band UVB, topical clobetasol and tacrolimus | Sustained resolution at 4-yr follow-up |
| 2017,S3 | Case report | 1 Female | 57 | White | Clofazimine | No improvement |
| 2017,S4 | Case report | 1 Female | 35 | NA | Fractionated nonablative laser and tacrolimus ointment | Improvement >75% and maintained at 5-mo follow-up |
| 2016,S5 | Case report | 1 Male | 48 | Asian | Isotretinoin | Recurrence upon discontinuation of treatment. |
| 2015,S6 | Retrospective study | 39 Female; 29 Male | 3-76 | Asian | Topicals: steroid, tretinoin, hydroquinone; dapsone, clofazimine, minocycline | Most exhibited no improvement or worsened progression at >1-yr follow-up |
| 2015,S7 | Case report | 1 Female; 1 Male | 19, 29 | NA | Topical tacrolimus | Resolution following therapy with no recurrence at 2- to 3-mo follow-up |
| 2015,S8 | Case report | 2 Female | 53, 59 | NA | Narrow-band UVB | Improvement noted |
| 2015,S9 | Case report | 1 Female | 25 | Hispanic | Topical clobetasol, pimecrolimus, tacrolimus; dapsone | No response to therapies; self-resolution noted at 5-yr follow-up |
| 2012,S10 | Preliminary study | 4 Female; 4 Male | 20-54 | NA | Nonablative fractional laser | No improvement |
| 2012,S11 | Randomized, observer-blinded study | 6, NA | NA | NA | Nonablative fractional laser therapy | No improvement |
| 2011,S12 | Case report | 1 Female | 11, 21 | Asian | Q-switched ruby laser | No improvement |
| 1 Male | ||||||
| 2010,S13 | Case report | 1 Male | 39 | Hispanic | Narrow-band UVB | Improvement following therapy |
| 2009,S14 | Case report | 1 Female | 34 | NA | Clofazimine | Resolution following therapy |
| 2004,S15 | Case report | 1 Male | 16 | NA | Dapsone | Resolution following therapy |
| 2001,S16 | Case report | 1 Male | 21 | Hispanic | Prednisone | Improvement following therapy |
| 2001,S17 | Case report | 1 Female | 48 | NA | Interferon-α and ribavirin | Improvement following therapy |
NA, Not available; UVB, ultraviolet B.