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. 2020 Feb 20;40(2):BSR20193629. doi: 10.1042/BSR20193629

Figure 5. Knockout TLR4 attenuates microglial activation without ameliorating LPS-enhanced hTau transmission.

Figure 5

(A) TLR4 KO attenuates LPS-enhanced microglia activation (IBA1) without affect astrocytes (GFAP) measured by immunohistochemical staining compared with WT-P301L-LPS mice. Hp scale bar, 200 μm; CA3 scale bar, 100 μm; DG scale bar, 100 μm. (B and C) Average optical density (AOD) was used to analyze the activation of microglia (B) and astrocytes (C). Data were present as mean ± SD (n = 3 each group, two-way ANOVA followed by Tukey post hoc test). ***, P < 0.001 versus WT-P301L-LPS.