Fig. 4.

Protein networks of Rg3(S)-treated senescent human dermal fibroblasts (HDFs). The directly interacting networks of proteins from old HDFs treated with 10 μM of Rg3(S) for (A) 2 h, (B) 6 h, and (C) 12 h were determined by Ingenuity Pathway Analysis. At each time point, networks 1 (main subnetwork) and 7 (peroxyredoxin-3–containing subnetwork) were merged to determine the molecular functional group. Red and green symbols indicate the proteins that are upregulated and downregulated, respectively, after Rg3(S) treatment.