Table 1.
Inhibitory effects of oleanolic acid 3-acetate on the growth of SKOV3 cell xenografts in nude mice
| Group | Before experiment |
After experiment |
Tumor weight (g) | Inhibition ratio (%) | ||
|---|---|---|---|---|---|---|
| n | Body weight (g) | n | Body weight (g) | |||
| Control | 6 | 21.00 ± 0.34 | 6 | 22.75 ± 2.90 | 2.19 ± 0.88 | |
| Cisplatin (5 mg/kg) | 6 | 22.38 ± 0.89 | 6 | 20.78 ± 1.37 | 1.08 ± 0.51* | 50.78 |
| Oleanolic acid 3-acetate (10 mg/kg) | 6 | 22.05 ± 1.01 | 6 | 22.91 ± 2.02 | 1.48 ± 0.46 | 32.50 |
| Oleanolic acid 3-acetate (20 mg/kg) | 6 | 21.58 ± 0.77 | 6 | 22.35 ± 0.98 | 1.35 ± 0.39* | 38.47 |
| Oleanolic acid 3-acetate (40 mg/kg) | 6 | 21.64 ± 0.88 | 6 | 22.96 ± 0.75 | 1.18 ± 0.38* | 46.02 |
SKOV3 cells were implanted s.c. under the left flanks of athymic mice. Animals were randomized into five groups and were treated with oleanolic acid 3-acetate by daily i.p. injection for 19 days: Control, treated with vehicle (0.1% DMSO diluted in saline); Cisplatin, treated with cisplastin at the dose of 5 mg/kg body weight (positive control); Oleanolic acid 3-acetate, treated with oleanolic acid 3-acetate at the dose of 10, 20, and 40 mg/kg body weight. The body weight of mice was measured every 3 days after initiating the treatment. The tumor weights were measured on sacrificing the mice at the 19th day after treatment. Data represented the means ± SD (n = 6). Tumor growth was significantly inhibited (∗p < 0.05 vs. the control).