Table 4.
Regression coefficients (95% CI, P-interaction) of different trial level covariates resulting from univariate meta-regression using the random effect model for the observational studies.
| Outcome | Covariate | Slope (95% CI) from univariate meta-regression |
P-for interaction | Number of observational studies |
|---|---|---|---|---|
| Gastrointestinal bleeding | Mean age; Study duration; Study quality |
0.04 (-0.00, 0.09); -0.05 (-0.23; 0.14); -0.57 (-1.02; 2.17) |
0.07; 0.60; 0.48 |
5 |
| Pneumonia | Mean age; Study duration; Study quality |
-0.02 (-0.05, 0.00); 0.08 (-0.01, 0.17); -0.11 (-0.55, 0.33); |
0.05; 0.08; 0.61; |
6 |
| Surgical site infection | Mean age; Study duration; Study quality |
-0.06 (-0.14; 0.02); 0.15 (-0.03, 0.33); 0.34 (-0.30, 0.99); |
0.15; 0.10; 0.30; |
5 |
| Urinary tract infections | Mean age; Study duration; Study quality |
0.03 (0.01, 0.05)*; -0.06 (-0.12, -0.01)*; 0.06 (-0.35, 0.48) |
<0.01; 0.03; 0.76 |
6 |
*Values in bold are statistically significant.