Table 1. Explanation on the functions in the caffsim R package.

Class	Functions	Description
Single dose	caffConcTime	Create a concentration-time dataset of single oral dosing of caffeine.
		Usage in R: caffConcTime(Weight = 20, Dose = 200, N = 20)
	caffPkparam	Create a dataset of pharmacokinetic parameters of single oral dosing of caffeine.
		Usage in R: caffPkparam(Weight = 20, Dose = 200, N = 20)
	caffPlot	Plot plasma concentration-time curves of single oral dosing of caffeine.
		Usage in R: caffPlot(caffConcTime(Weight = 20, Dose = 200, N = 20))
Mulitple doses	caffConcTimeMulti	Create a concentration-time dataset of multiple oral dosing of caffeine.
		Usage in R: caffConcTimeMulti(Weight = 20, Dose = 200, N = 20, Tau = 8, Repeat = 4)
	caffPkparamMulti	Create a dataset of pharmacokinetic parameters of multiple oral dosing of caffeine.
		Usage in R: caffPkparamMulti(Weight = 20, Dose = 200, N = 20, Tau = 8)
	caffPlotMulti	Plot plasma concentration-time curves of multiple oral dosing of caffeine.
		Usage in R: caffPlotMulti(caffConcTimeMulti(Weight = 20, Dose = 200, N = 20, Tau = 8, Repeat = 4))
Others	caffDescstat	Calculate descriptive statistics of simulated pharmacokinetic parameters.
		Usage in R: caffDescstat(caffPkparam(20,500))
	caffOverdose	Calculate a duration of toxic concentration over specified levels (40 mg/L or 80 mg/L).
		Usage in R: caffOverdose(caffConcTime(Weight = 20, Dose = 200, N = 20))
	caffShiny	Run Shiny app to interactively simulate single and multiple dosing for plasma caffeine concentration.
		Usage in R: caffShiny()
	UnitTable	Unit data of PK parameters.
		Usage in R: UnitTable