Table 2.
Summary of results of the studies included in this meta-analysis.
| References | Diagnostic methods | TP | FP | FN | TN | Sensitivity (%) | Specificity (%) | PLR | NLR |
|---|---|---|---|---|---|---|---|---|---|
| Karstrup et al. (25) | FNA | 15 | 5 | 3 | 17 | 0.83 (0.59, 0.96) | 0.77 (0.55, 0.92) | 3.67 (1.65, 8.14) | 0.22 (0.07, 0.62) |
| CNB | 14 | 1 | 4 | 17 | 0.78 (0.52, 0.94) | 0.94 (0.73, 1.00) | 14.00 (2.05, 95.56) | 0.24 (0.10, 0.56) | |
| Renshaw and Pinnar (26) | FNA | 29 | 21 | 2 | 10 | 0.94 (0.79, 0.99) | 0.32 (0.17, 0.51) | 1.38 (1.06, 1.79) | 0.20 (0.05, 0.84) |
| CNB | 20 | 17 | 11 | 14 | 0.65 (0.45, 0.81) | 0.45 (0.27, 0.64) | 1.18 (0.78, 1.78) | 0.79 (0.43, 1.45) | |
| Na et al. (12) | FNA | 46 | 0 | 33 | 70 | 0.58 (0.47, 0.69) | 1.00 (0.95, 1.00) | 82.54 (5.18, 1314.94) | 0.42 (0.33, 0.55) |
| CNB | 65 | 1 | 14 | 69 | 0.82 (0.72, 0.90) | 0.99 (0.92, 1.00) | 57.59 (8.21, 404.25) | 0.18 (0.11, 0.29) | |
| Sung et al. (14) | FNA | 218 | 0 | 100 | 237 | 0.69 (0.63, 0.74) | 1.00 (0.98, 1.00) | 326.04 (20.43, 5202.61) | 0.32 (0.27, 0.37) |
| CNB | 276 | 2 | 42 | 235 | 0.87 (0.83, 0.90) | 0.99 (0.97, 1.00) | 102.85 (25.86, 409.11) | 0.13 (0.10, 0.18) | |
| Hakala et al. (23) | FNA | 12 | 0 | 12 | 28 | 0.50 (0.29, 0.71) | 1.00 (0.88, 1.00) | 29 (1.81, 465.42) | 0.51 (0.34, 0.76) |
| CNB | 14 | 1 | 10 | 27 | 0.58 (0.37, 0.78) | 0.96 (0.82, 1.00) | 16.33 (2.31, 115.28) | 0.43 (0.27, 0.70) | |
| Chen et al. (21) | FNA | 3 | 0 | 1 | 12 | 0.75 (0.19, 0.99) | 1.00 (0.74, 1.00) | 18.2 (1.13, 292.75) | 0.31 (0.08, 1.20) |
| CNB | 26 | 4 | 6 | 53 | 0.81 (0.64, 0.93) | 0.93 (0.83, 0.98) | 11.58 (4.44, 30.22) | 0.20 (0.10, 0.42) | |
| Choi et al. (22) | FNA | 27 | 1 | 14 | 75 | 0.66 (0.49, 0.80) | 0.99 (0.93, 1.00) | 50.05 (7.05, 355.12) | 0.35 (0.23, 0.53) |
| CNB | 49 | 0 | 11 | 69 | 0.82 (0.70, 0.90) | 1.00 (0.95, 1.00) | 113.61 (7.16, 1803.15) | 0.19 (0.11, 0.32) | |
| Ahn et al. (20) | FNA | 174 | 5 | 135 | 176 | 0.56 (0.51, 0.62) | 0.97 (0.94, 0.99) | 20.38 (8.54, 48.65) | 0.45 (0.39, 0.51) |
| CNB | 45 | 0 | 23 | 71 | 0.66 (0.54, 0.77) | 1.00 (0.95, 1.00) | 94.96 (5.97, 1511.4) | 0.34 (0.25, 0.48) | |
| Suh et al. (27) | FNA | 340 | 3 | 90 | 1,757 | 0.79 (0.75, 0.83) | 1.00 (1.00, 1.00) | 463.88 (149.6, 1438.4) | 0.21 (0.17, 0.25) |
| CNB | 524 | 0 | 136 | 1,043 | 0.79 (0.76, 0.82) | 1.00 (1.00, 1.00) | 1656.82 (103.67, 26478.25) | 0.21 (0.18, 0.24) | |
| Hong et al. (24) | FNA | 238 | 0 | 43 | 405 | 0.85 (0.80, 0.89) | 1.00 (0.99, 1.00) | 686.74 (43.01, 10965.62) | 0.15 (0.12, 0.20) |
| CNB | 267 | 0 | 14 | 405 | 0.95 (0.92, 0.97) | 1.00 (0.99, 1.00) | 770.25 (48.25, 12295.09) | 0.05 (0.03, 0.08) | |
| Pooled value | FNA | 1,409 | 36 | 451 | 3,031 | 0.72 (0.69, 0.74) | 0.99 (0.98, 0.99) | 41.71 (2.15, 808.27) | 0.31 (0.22, 0.42) |
| CNB | 1,476 | 26 | 293 | 2,180 | 0.83 (0.81, 0.85) | 0.99 (0.98, 0.99) | 51.56 (3.20, 841.47) | 0.22 (0.15, 0.32) |
FNA, fine-needle aspiration; CNB, core needle biopsy; FN, False-negative; FP, False-positive; TN, True-negative; TP, True-positive; PLR, positive likelihood ratio; NLR, negative likelihood ratio.