TABLE 1.
Compounds | Minimum inhibitory concentration, MIC (μg/mL) |
HC50 (μg/mL) | Selectivity Index |
|||
MRSA | E. coli | C. albicans | HC50/MICMRSA | HC50/MICC. albicans | ||
ACM-NBut (4) | >1024 | >1024 | >1024 | >2048 | – | – |
ACM-NHex (5) | 16 | 128 | 32 | >2048 | >128 | >64 |
ACM-NOct (6) | 8–16 | 32 | 32 | >2048 | >128–256 | 32 |
ACM-NDec (7) | 2 | 4–8 | 1 | 260 | 130 | 260 |
ACM-EBut (8) | 128 | >1024 | >1024 | >2048 | >16 | – |
ACM-EHex (9) | 8–16 | 32 | 16 | 750 | 47–93 | 93 |
ACM-EOct (10) | 4 | 8 | 4 | 25 | ∼6 | ∼6 |
ACM-ABut (11) | 16–32 | 256 | >1024 | >2048 | >64–128 | – |
ACM-AHex (12) | 2–4 | 8 | 4 | 270 | 67–135 | 67 |
ACM-AOct (13) | 4 | 16 | 4 | 45 | ∼10 | 2.5 |
Vancomycin | 0.5–1 | aN.D. | N.D. | N.D. | N.D. | N.D. |
Colistin | N.D. | 1 | N.D. | N.D. | N.D. | N.D. |
Amphotericin B | N.D. | N.D. | <0.25 | N.D. | N.D. | N.D. |
aN.D. stands for not determined.