Skip to main content
. 2020 Feb 14;8:55. doi: 10.3389/fbioe.2020.00055

TABLE 1.

Antimicrobial and hemolytic activity of the amphiphilic cationic macromolecules (ACMs).

Compounds Minimum inhibitory concentration, MIC (μg/mL)
HC50 (μg/mL) Selectivity Index
MRSA E. coli C. albicans HC50/MICMRSA HC50/MICC. albicans
ACM-NBut (4) >1024 >1024 >1024 >2048
ACM-NHex (5) 16 128 32 >2048 >128 >64
ACM-NOct (6) 8–16 32 32 >2048 >128–256 32
ACM-NDec (7) 2 4–8 1 260 130 260
ACM-EBut (8) 128 >1024 >1024 >2048 >16
ACM-EHex (9) 8–16 32 16 750 47–93 93
ACM-EOct (10) 4 8 4 25 ∼6 ∼6
ACM-ABut (11) 16–32 256 >1024 >2048 >64–128
ACM-AHex (12) 2–4 8 4 270 67–135 67
ACM-AOct (13) 4 16 4 45 ∼10 2.5
Vancomycin 0.5–1 aN.D. N.D. N.D. N.D. N.D.
Colistin N.D. 1 N.D. N.D. N.D. N.D.
Amphotericin B N.D. N.D. <0.25 N.D. N.D. N.D.

aN.D. stands for not determined.