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. 2020 Feb 14;8:90. doi: 10.3389/fbioe.2020.00090

TABLE 1.

Gene ontology analysis.

CHI3L1 ANG PTX3 TSP-1 DKK-1 uPAR OPN VEGF P
Response to external stimulus * * * * * * * 7 3.3E-6
Defense response * * * * * 5 2.8E-4
Positive regulation of metabolic process * * * * * 5 5.2E-3
Regulation of phosphorylation * * * * * * 6 1.8E-4
Regulation of response to stress * * * * 4 1.9E-2
Angiogenesis * * * * 4 7.7E-4
Endocytosis * * * * 4 3.1E-3
Secretion * * * * 4 1.2E-2
Homeostatic process * * * 3 3.7E-2
Immune response * * * 3 3.2E-2
Response to wounding * * * 3 2.1E-3
Response to oxygen levels * * * 3 9.2E-3
Negative regulation of cell death * * * 3 1.1E-1
Cell migration * * * 3 1.1E-1

Biological processes identified by cytokine clustering from 3 to 7 of the selected cytokines. ANG: angiogenin; CHI3L1: chitinase-3-like-1; DKK-1: dickkopf-1 WNT signaling pathway inhibitor; NGAL: lipocalin-2; OPN: osteopontin; PTX-3: pentraxin-3; TSP-1: thrombospondin-1; uPAR: plasminogen activator, urokinase; VEGF: vascular endothelial growth factor.