TABLE 2.

Gene Ontology analysis of cytokine array on EVs.

	APOA1	ANG	DKK1	EMMPRIN	FGF19	IL8	KLK3	NGAL	MMP9	OPN	PTX3	RETN	SDFlα	PAI1	THSP1	uPAR	N°	P
Defense response	*	*				*	*	*		*	*	*	*	*	*	*	12	9.2E-8
Movement of cells or subcellular component	*	*		*	*	*			*			*	*	*	*	*	11	3.7E-7
Regulation of angiogenesis						*	*							*	*		4	9.5E-4
Cell proliferation	*	*			*	*			*			*	*		*		8	6.1E-4
Wound healing	*									*				*	*	*	5	2.2E-3
Regeneration	*									*			*				3	8.5E-3
Homeostatic process	*	*						*		*			*				5	4.2E-2

Biological processes identified by cytokine clustering from 3 to 12 of the selected cytokines. APOA1: Apolipoprotein A1; ANG: angiogenin; DKK-1: dickkopf-1 WNT signaling pathway inhibitor; FGF-19: fibroblast growth factors; IL8: interleukin-8; KLK3: Kallikrein 3; NGAL: lipocalin-2; MMP-9: metalloproteinase-9; OPN: osteopontin; PTX-3: pentraxin-3; RETN: resistin; SDF-1α: stromal cell derived factor 1α; PAI-1: serpin E1; THSP-1: thrombospondin-1; uPAR: plasminogen activator, urokinase.