Table 2.

ISSUE-3 and SPAIN trials compared.

	ISSUE-3	SPAIN
Diagnostic tool	Implantable loop recorder	Head-up tilt table
Number of patients included	77	54
Design	Double-blind, randomized, placebo-controlled, and parallel	Double-blind, randomized, placebo-controlled, and cross-over
Pacing mode	DDD-rate drop response	DDD-closed loop stimulation
Follow-up (months)	24	12
Recurrence rate in placebo arm (%)	57	45.7
Recurrence rate in pacing arm (%)	25	8.7
Relative risk reduction (%)	57	89
Absolute risk reduction (%)	Unknown	37
NNT	Unknown	2.7