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. 2020 Jan 16;19:1276–1289. doi: 10.1016/j.omtn.2020.01.002

Figure 7.

Figure 7

KDM3A Inhibits TGIF1 Expression to Accelerate the Progression of Chronic Renal Fibrosis

(A) The expression of TGIF1 in cells assessed by qRT-PCR. *p < 0.05 versus control cells; #p < 0.05 versus AA-incubated cells transfected with sh-NC; &p < 0.05 versus AA-incubated cells transfected with + oe-NC. (B) Western blot analysis of Col1a1, fibronectin, α-SMA, and TGIF1 proteins. *p < 0.05 versus AA-incubated cells transfected with oe-NC. (C) The expression of TGIF1 in kidney tissues of mice assessed by qRT-PCR. *p < 0.05 versus sham-operated mice; #p < 0.05 versus UUO mice treated with sh-NC; &p < 0.05 versus UUO mice treated with oe-NC. (D) Immunohistochemistry analysis of Col1a1, fibronectin, and α-SMA proteins in kidney tissues of mice (original magnification, ×200). (E) Masson’s trichrome staining of kidney tissues of mice (original magnification, ×200). The above data were all measurement data and are expressed as mean ± standard deviation. Data between two groups were compared by an unpaired t test. Data among multiple groups were analyzed by one-way ANOVA, followed by a Tukey’s multiple comparisons post-test. The cell experiment was conducted in triplicate.