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. 2020 Feb 14;7:14. doi: 10.3389/fmolb.2020.00014

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Copyright © 2020 Beauchamp, Jackson, Ozhathil, Agarkova, Galindo, Sawyer, Suter and Zuppinger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Contraction features in small and large multicellular aggregates, and effects of cardiotoxic substances. (A) Features of spontaneous contractions of small and large aggregates (50 ± 8 and 400 ± 47 μm in diameter) of hiPSC-CMs and CF were investigated. (B) The cardiotoxic cancer therapy doxorubicin (Doxo) was added to co-culture spheroids. The spheroids were electrically paced at 3 Hz (the corresponding value is indicated by an arrow in the y-axis for the p-p parameter) (C) The effect of Doxo on 2D cultured hiPSC-CMs. N = 4–6 spheroids per group or fields in 2D-cultures, *p < 0.05, **p < 0.01.