Table 1.

Results are provided for the ROI's with significant post- vs. pre-treatment differences in the NAC and control subjects, i.e., with the presence of treatment group and timing interaction.

Brain structure	Group	Post- vs. pre-difference	p-value	95% CI
Inferior frontal gyrus	Control group	−0.060	0.993	(−0.456, 0.336)
	NAC group	0.441	0.022	(0.044, 0.837)
Lateral temporal gyrus	Control group	−0.805	0.039	(−1.579, −0.031)
	NAC group	0.854	0.025	(0.080, 1.629)
Middle temporal gyrus	Control group	−0.774	0.072	(−1.595, 0.046)
	NAC group	0.982	0.012	(0.162, 1.803)
Temporal lobe	Control group	−0.954	0.093	(−2.015, 0.106)
	NAC group	1.000	0.072	(−0.061, 2.061)
Caudate	Control group	−0.100	0.952	(−0.497, 0.297)
	NAC group	0.606	<0.001	(0.209, 1.003)
MHI cognition	Control group	−3.056	0.744	(−10.188, 4.076)
	NAC group	8.611	0.010	(1.479, 15.742)
PDQ attention	Control group	0.917	0.305	(−0.413, 2.246)
	NAC group	−1.417	0.031	(−2.746, −0.087)

The p-values provided are for each group and the regions listed are those that were significantly different between the two groups at a p < 0.05 corrected for multiple comparisons. Similarly, the table shows the self-reported scores of cognition and attention with the presence of treatment group and timing interaction. These were the only clinical measures that were significantly improved in the NAC group compared to the control group (p < 0.05 corrected for multiple comparisons). Other measures of pain, fatigue, anxiety, depression, and overall physical function were not significantly different between the two groups.