FIGURE 1.

Experimental design. Three experiments were performed to examine the therapeutic effect of human PRP on endometrial regeneration. In Experiment 1, the mice were euthanized at 14 days after uterine horn damage (7 days after PRP treatment) and the effects on endometrial regeneration were assessed by evaluating endometrial histology and expression of fibrosis-related factors. In Experiments 2 and 3, the mice were mated at 14 days after experiment initiation (7 days after PRP treatment) and followed-up until mid-gestation and delivery, respectively. In Experiment 2, the mice were euthanized on day 12 of pregnancy to examine the implantation sites. In Experiment 3, the pregnancy outcomes were evaluated.