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. 2020 Feb 14;11:105. doi: 10.3389/fphys.2020.00105

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Copyright © 2020 Kim, Park, Paek, Lee, Song and Lyu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Infusion of human PRP is associated with better implantation outcomes. (A) Design of Experiment 2. In AS mice, injury was induced to the bilateral uterine horns; at 7 days after bilateral injury, PRP was injected only in the right uterine horn. At 14 days after experiment initiation (7 days after PRP treatment), AS mice were mated with fertile, healthy males. (B) Gross morphology of the implantation sites (IS) in AS mice with or without PRP. (C) The number of the IS in the PRP-treated horn of AS mice. (D) Photographs of embryos isolated from the IS on day 12 of pregnancy. (E) A graph for the weights of IS between the AS group and the PRP-treated AS group on day 12 of pregnancy. The horizontal yellow lines represent median values. Sham, n = 4; AS or PRP-treated AS, n = 5. *p < 0.01; **p < 0.05. AS, Asherman’s syndrome; PRP, platelet-rich plasma.