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. 2020 Feb 14;11:105. doi: 10.3389/fphys.2020.00105

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Copyright © 2020 Kim, Park, Paek, Lee, Song and Lyu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PRP treatment is associated with improved live-birth rates in mice with AS. (A) Design of Experiment 3. At 7 days after inducing injury to the bilateral uterine horns, half of the AS mice received PRP treatment to the bilateral horns (PRP-treated AS group), whereas the other half were followed up without PRP treatment (AS group). All mice were mated to healthy males at 14 days after experiment initiation. (B) Representative photographs of PRP-treated AS mice with pups after successful delivery and of AS mice which failed to deliver. (C–E) Therapeutic effects of PRP on the time to conceive (C), delivery rate (D), and litter size (E) in AS mice. Sham, n = 4; AS, n = 6; PRP-treated AS, n = 6. *p < 0.01; **p < 0.05. AS, Asherman’s syndrome; PRP, platelet-rich plasma.