TABLE 2.
High-level linezolid resistance leads to the decreased sensitivity of Enterococcus faecalis to radezolid.
| Isolates | MIC (mg/L) | 23S rRNA mutations | ||||
| LZD | RZD | R1 | R2 | R3 | R4 | |
| ATCC29212-0 | 2 | 0.25 | – | – | – | – |
| ATCC29212-6 | 8 | 0.25 | C2424U | – | – | G2576U |
| ATCC29212-10 | 16 | 0.5 | C2424U | – | – | G2576U |
| ATCC29212-18 | 64 | 1 | C2424U | – | G2576U | G2576U |
| ATCC29212-22 | 128 | 1 | C2424U | – | G2576U | G2576U |
| ATCC29212-27 | 256 | 4 | C2424U | G2576U | G2576U | G2576U |
| ATCC29212-47 | 256 | 8 | C2424U | G2576U | G2576U | G2576U |
| OG1RF-0 | 2 | 0.25 | – | – | – | – |
| OG1RF-5 | 8 | 0.25 | G2576U | – | G2505A | – |
| OG1RF-8 | 16 | 1 | G2576U | – | G2505A | G2576U |
| OG1RF-18 | 64 | 4 | G2576U, C2610A | G2576U, C2610A | G2505A | G2576U, C2610A |
| OG1RF-25 | 128 | 4 | G2576U, C2610A | G2576U, C2610A | G2505A | G2576U, C2610A |
| OG1RF-30 | 256 | 4 | G2576U, C2610A | G2576U, C2610A | G2505A | G2576U, C2610A |
| OG1RF-55 | 256 | 8 | G2576U, C2610A | G2576U, C2610A | G2505A | G2576U, C2610A |
RZD, radezolid; LZD, linezolid; MIC, minimum inhibitory concentration.