Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 14;8:77. doi: 10.3389/fcell.2020.00077

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Nwadozi, Rudnicki and Haas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Metabolism of pericytes during proliferation and quiescence. Top: Under growth factor stimulation, pericytes increase glucose metabolism (black arrows) to support proliferation. Pericytes increase glucose uptake via GLUT1 and GLUT4 transporters and glucose is metabolized to produce ATP predominantly through glycolysis. This metabolic pathway also provides precursors to protein glycosylation that are essential to the production of capillary basement membrane proteoglycans. Although nucleotide synthesis may be supported by glycolysis via the pentose phosphate pathway (dashed arrow), current data indicate that fatty acid-derived carbons are incorporated into dNTP synthesis in pericytes. Fatty acid oxidation (red arrows) also contributes to the bioenergetic demand during proliferation, generating up to 15% of the total ATP content. Bottom: Quiescence is associated with a low metabolic state and downregulation of all metabolic programs. However, the relative contributions of glycolysis, glucose oxidation and fatty acid oxidation (illustrated with dashed arrows) within quiescent pericytes have not been established. α-KG, alpha-Ketoglutarate; ATP, Adenosine triphosphate; FA, fatty acid; FAO, fatty acid oxidation; Glc, glucose; HBP, hexosamine biosynthesis pathway; PPP, pentose phosphate pathway; R5P, Ribose 5-phosphate; TCA, Tricarboxylic acid; UDP-GlcNac, Uridine 5′-diphospho-N-acetylglucosamine.