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Expression of c-Maf in T cells regulates tolerance/sensitivity to microbiota in the gut. Expression of c-Maf in regulatory T cells (Foxp3+ RORγt− or Foxp3+ RORγt+) as well as in Th17 cells (RORγt+ Foxp3−) regulates the expression level of IL-10 in the colon and is central in the regulation of tolerance to gut microbiota.
