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. 2020 Feb 14;8:56. doi: 10.3389/fcell.2020.00056

FIGURE 1.

FIGURE 1

More M1 macrophages infiltrate in calcified aortic valves, with a reduction of IL-37 expression. (A) Normal and calcified human aortic valves were stained with HE. The arrow above shows the newly blood vessels in calcified aortic valves. Magnification, 200× and 400×; n = 6. (B–D) CD11c, CD206 and IL-37 expression are shown in calcified and non-calcified aortic valves. Magnification, 200× and 400×; n = 6. (E) Integrated optical density (IOD)/area of CD11c, CD206 and IL-37. Magnification, 400×, scale bar = 50 μm. (F) CD11c + cell-to-CD206 + cell ratio in CAVD and non-CAVD. Data are presented as the mean ±SD (n = 6); *P < 0.05, **P < 0.01. HE, hematoxylin-eosin; CAVD, calcific aortic valve disease; non-CAVD, non-calcific aortic valve disease.