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IL-37 promotes the expression of M2 macrophage markers.(A) Representative immunoblots and densitometric data show that CD206 expression increases after pre-treating PMA-treated THP-1 cells with recombinant human IL-37 (0.1 ng/ml) prior to stimulating with LPS (100 ng/ml) and IFN-γ (20 ng/ml); n = 3, *P < 0.05. (B) The ELISA data show that IL-37 up-regulates IL-10 secretion; n = 4, **P < 0.01, ***P < 0.001.
