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. 2020 Feb 3;34:136–145. doi: 10.1016/j.molmet.2020.01.011

Figure 4.

Figure 4

RNA sequencing in MBOAT7 deficient ccRCC cells reveals alterations in cell cycle, matrix organization, and cell migration. (A) Heatmap of the top 25 and bottom 25 differentially expressed transcripts from unbiased RNAseq. (B) Pathway analysis revealed regulation of migration, cell proliferation, and extracellular organization from the top 250 significantly upregulated transcripts. (C) qPCR validation of selected genes altered in MBOAT7 null Caki-1 cells. RNAseq and qPCR validation data represent n = 4 per group biological replicates. Student's t-test and p-value: *<0.05, **<0.002, ***<0.0002, and ****<0.0001.