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. 2020 Feb 13;14:7. doi: 10.3389/fnsys.2020.00007

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Copyright © 2020 Lackey and Sillitoe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship between Purkinje cell zones and spinocerebellar mossy fiber zones is disrupted in ephrin-A2^−/−;ephrin-A5^−/− mutant mice. (A–C) Image of the WGA-Alexa 555 signal and zebrinII expression in the anterior cerebellum of a control mouse (N = 6). The patterning of the spinocerebellar mossy fiber zones has a systematic relationship to the map defined by the Purkinje cell zones. d, dorsal, v, ventral. Scale = 100 μm. (D–F) Image of the WGA-Alexa 555 signal and zebrinII expression in the anterior cerebellum of an ephrin-A2^−/−;ephrin-A5^−/− double knockout mouse (N = 3). The relationship between spinocerebellar terminal field zones (S1a and S2a) and the boundaries of the Purkinje cell zones (P1+ and P2+) is disrupted due to the poorly defined spinocerebellar zone boundaries (yellow arrows).