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. 2020 Feb 14;11:88. doi: 10.3389/fphys.2020.00088

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Copyright © 2020 DelGiorno, Naeem, Fang, Chung, Ramos, Luhtala, O’Connor, Hunter, Manor and Wahl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pancreatitis-induced tuft cells in wild type CD1 mice express cytokine IL-25. (A) RNA-seq demonstrating significantly higher expression of Il25 in tuft cells (EpCAM+; Siglec f+ cells) as compared to non-tuft epithelial cells (EpCAM+; Siglec f-neg cells). (B) RT-qPCR confirms significantly higher Il25 expression in tuft cells. (C) Co-immunofluorescence for red fluorescent protein (RFP, red) and phalloidin (green) in Il25^F25/F25 mice with pancreatitis. Scale bar, 5 μm. *p < 0.05; ****p < 0.001.