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. 2020 Feb 14;11:24. doi: 10.3389/fmicb.2020.00024

FIGURE 1.

FIGURE 1

MicroRNAs (miRNAs) of the miR-15/16 family with identical seed sequences inhibit dengue virus 2 (DENV2). (A) Comparison of the seed sequences of the members of the miR-15/16 family of miRNAs. Identical seed sequences (nucleotides 2–7) are highlighted in blue; the seed sequences of miR-103 and miR-107 (in green) are similar but offset by one nucleotide. (B) HeLa cells were transfected with the indicated miR-15/16 family member duplex RNA mimics, a validated non-targeting miRNA mimic (miR-Ct) as a negative control, or a DENV2 genome siRNA (DENV2 siR) and infected with DENV2 (MOI = 3 ffu/cell) 2 days post-transfection. Supernatants were collected 3 days p.i. and titered on Vero cells.