Figure 6. . Steady state levels of transsulfuration/glutathione biosynthesis metabolites in cisplatin-resistant ovarian cancer cell lines compared with respective parent cell lines OVCAR-5 and SKOV-3.

Cisplatin-resistant ovarian cancer cells exhibit elevated levels of transsulfuration pathway metabolites (cystathionine and Cys) and GSH biosynthesis pathway metabolites (γ-Glu-Cys and GSH). Data representative of at least n = 3 individual experiments.

*p< 0.05.

Cys: Cysteine; Glu: Glutamic acid; GSH: Glutathione.