Table 1. Characteristics of the enrolled patients.
| Variable | Type 1 AIH control group (n = 50) | AHE group (n = 198) | P |
|---|---|---|---|
| Clinical characteristics | |||
| Age (y) | 56.7 (42.50–68.90) | 55.3 (43.31–69.20) | 0.281 |
| Females | 84.0% (42/50) | 56.1% (111/198) | 0.0003 |
| BMI | 22.63 ± 2.27 | 23.21 ± 2.12 | 0.090 |
| Laboratory parameters | |||
| WBC (109/L) | 6.22 (5.50–8.58) | 6.37 (5.59–8.96) | 0.087 |
| RBC (1012/L) | 4.20 ± 0.67 | 4.15 ± 0.72 | 0.657 |
| ALT (U/L) | 265.00 (122.00–875.00) | 534.00 (139.00–1498.00) | 0.001 |
| AST (U/L) | 329.00 (84.00–992.00) | 377.00 (98.00–1190.00) | 0.086 |
| GGT (U/L) | 95.00 (55.58–170.00) | 99.00 (56.50–175.00) | 0.198 |
| TP (g/L) | 58.76 ± 9.12 | 57.20 ± 8.12 | 0.238 |
| ALB(g/L) | 30.76 ± 5.61 | 31.39 ± 5.62 | 0.479 |
| UREA (mmol/L) | 4.51 (3.58–6.95) | 4.59 (3.72–7.05) | 0.365 |
| CR (umol/L) | 75.12 (63.55–92.50) | 76.22 (64.55–95.60) | 0.176 |
| PT (s) | 17.08 (14.02–21.09) | 17.45 (14.22–23.55) | 0.116 |
| PLT (109/L) | 135.00 (89.00–168.00) | 138.00 (91.00–174.00) | 0.169 |
| AFP (ng/ml) | 33.41 (7.98–108.00) | 37.20 (6.90–125.80) | 0.217 |
| TBIL (umol/L) | 55.87 ± 9.32 | 295.57 ± 159.12 | 0.000 |
| CHE (U/L) | 3855.00 (2150.40–4916.90) | 2728.50 (2345.52–3312.68) | 0.001 |
| CRP (mg/L) | 9.89 (6.76–13.98) | 10.22 (7.01–14.09) | 0.082 |
| INR | 1.80 (1.35–2.32) | 1.77 (1.29–2.15) | 0.198 |
| HEV-IgM (+) | 0.0% (0/50) | 80.3% (159/198) | <0.0001 |
| HEV-IgG (+) | 14.0% (7/50) | 84.8% (168/198) | <0.0001 |
| Symptoms | |||
| Jaundice | 4.0% (2/50) | 71.2% (141/198) | <0.0001 |
| Fever | 2.0% (1/50) | 57.1% (113/198) | <0.0001 |
| Nausea/vomit | 14.0% (7/50) | 70.2% (139/198) | <0.0001 |
| Abdominal pain | 20.0% (10/50) | 24.2% (48/198) | 0.527 |
Note: AST, Glutamic oxaloacetic transaminase; ALT, Alanine aminotransferase; AFP, Alpha fetoprotein; WBC, white blood cell; RBC, red blood count; CHE, cholinesterase; UREA, urea nitrogen; CR, creatinine; PT, prothrombin time; TBIL, total bilirubin; ALB, albumin; INR, international normalized ratio; PLT, platelet; CRP, c-reactive protein.