Figure 1.

Identification and comparison of cellular proteins with or without HBV identified by IP-MS. (A) HEK293T cells were transfected with HA-tagged A3B with or without HBV replication plasmid. The cell lysates were coimmunoprecipitated using anti-HA antibody and analysed by SDS-PAGE, and then the gel was processed for MS. (B) Diagrams describe the number of proteins interacting with A3B identified in the MS data in the presence or absence of HBV. (C) A3B PPI constructed based on enriched GO annotations. Edge thickness describes the confidence score for interactions determined by the STRING database, and the node colour describes the number of unique peptides derived from the mass spectrometry analysis.