Table 5.
Patient Characteristics, Treatment Strategies, and Outcomes According to Anticoagulation Therapy at Discharge
| Warfarin (N=23 191) | Edoxaban (N=8260) | Rivaroxaban (N=3373) | Apixaban (N=2600) | |
|---|---|---|---|---|
| Patient characteristics | ||||
| Age, y | 67.8±15.6 | 68.7±15.3 | 66.0±15.1 | 69.3±15.1 |
| Women | 13 156 (57%) | 4901 (59%) | 1789 (53%) | 1516 (58%) |
| Body weight, kg | 57.8±18.2 | 57.5±17.9 | 59.7±18.4 | 58.3±17.7 |
| Cancer | 4070 (18%) | 1728 (21%) | 507 (15%) | 419 (16%) |
| PE with or without DVT | 10 942 (47%) | 4726 (57%) | 1994 (59%) | 1545 (59%) |
| Treatment strategies | ||||
| Parenteral anticoagulation therapy with unfractionated heparin | 20 710 (89%) | 6765 (82%) | 2369 (70%) | 1778 (68%) |
| Thrombolysis | 2342 (10%) | 698 (8.5%) | 344 (10%) | 200 (7.7%) |
| Inferior vena cava filter use | 5566 (24%) | 1582 (19%) | 667 (20%) | 481 (19%) |
| Outcomes | ||||
| Length of hospital stay, d | 16 (11‐24) | 13 (9‐19) | 13 (9‐20) | 13 (9‐19) |
| Length of hospital stay in PE patients, d | 18 (13‐26) | 14 (10‐20) | 14 (10‐20) | 14 (10‐20) |
| Length of hospital stay in DVT patients, d | 15 (10‐22) | 12 (7‐18) | 12 (8‐18) | 12 (8‐17) |
| Cost of hospitalization (Japanese yen) | 750 422 (481 691‐1 176 026) | 648 740 (426 355‐1 021 018) | 681 706 (441 262‐1 065 280) | 655 103 (435 890‐985 990) |
| Cost of hospitalization in PE patients (Japanese yen) | 957 239 (648 433‐1 401 474) | 757 008 (514 060‐1 115 912) | 766 302 (524 554‐1 133 127) | 724 741 (505 599‐1 045 703) |
| Cost of hospitalization in DVT patients (Japanese yen) | 580 384 (401 938‐946 000) | 511 824 (353 912‐860 228) | 557 630 (354 136‐928 708) | 530 698 (366 654‐881 156) |
| Cost of hospitalization (US dollarsa) | 6822 (4379‐10 691) | 5898 (3876‐9282) | 6197 (4011‐9684) | 5956 (3963‐8964) |
| Cost of hospitalization in PE patients (US dollarsa) | 8702 (5895‐12 741) | 6882 (4673‐10 145) | 6966 (4769‐10 302) | 6589 (4596‐9506) |
| Cost of hospitalization in DVT patients (US dollarsa) | 5277 (3654‐8600) | 4653 (3217‐7820) | 5069 (3220‐8443) | 4825 (3333‐8011) |
Categorical variables are presented as numbers and percentages. Continuous variables are presented as the median and interquartile range. DVT indicates deep vein thrombosis; PE, pulmonary embolism.
a
1 dollar=110 Japanese yen.