Table 2.

Significant Predictors of Hospital Mortality on Multivariate Logistic Regression With Nonadaptive Elastic Net Penalization

	Adjusted OR	OR 95% CI	P Value
Age	1.024	1.016 to 1.033	<0.001
APACHE‐III score	1.011	1.006 to 1.017	<0.001
Maximum week 1 SOFA	1.252	1.190 to 1.318	<0.001
Admission sodium level	0.970	0.951 to 0.989	0.002
Admission BUN level	1.010	1.004 to 1.016	<0.001
No. of vasoactive drugs	1.194	1.070 to 1.333	0.002
Discharge diagnosis of AF	0.729	0.587 to 0.906	0.004
Discharge diagnosis of cardiac arrest	3.840	2.835 to 5.201	<0.001
Discharge diagnosis of CAD	0.606	0.470 to 0.781	<0.001
Discharge diagnosis of respiratory failure	1.727	1.300 to 2.296	<0.001

Only predictors with P<0.01 are shown. Predictors with borderline significance (P=0.01–0.1) included in the model were: cardiomyopathy, Charlson comorbidity index, heart rate, HF, hospital days preceding CICU admission, invasive ventilator use, oxygen saturation, PCI, respiratory rate, and systolic BP. Additional predictors included in the model with P≥0.1 were white race, year of CICU admission, noninvasive ventilator use, potassium, bicarbonate, creatinine, previous MI, previous stroke, previous CKD, previous diabetes mellitus, previous lung disease, CRRT, diastolic BP, previous dialysis, new dialysis start, PAC, coronary angiogram, ACS, ESRD, and sepsis. The validation AUC was 0.908 for the final model. ACS indicates acute coronary syndrome; AF, atrial fibrillation; APACHE, Acute Physiology and Chronic Health Evaluation; AUC, area under the curve; BP, blood pressure; BUN, blood urea nitrogen; CAD, coronary artery disease; CICU, cardiac intensive care unit; CKD, chronic kidney disease; CRRT, continuous renal replacement therapy; ESRD, end‐stage renal disease; HF, heart failure; MI, myocardial infarction; OR, odds ratio; PAC, pulmonary artery catheterization; PCI, percutaneous intervention; SOFA, Sequential Organ Failure Assessment.