Table 4.
Incidences and Rates of MACE at 4 Years of Follow‐Up
| All | Total Established Disease | Any CADa | Any CVDa | Any PADa | Multiple Risk Factors Only | |
|---|---|---|---|---|---|---|
| N=625 951 Events/100 PY (95% CI) n (%) | N=217 536 Events/100 PY (95% CI) n (%) | N=110 456 Events/100 PY (95% CI) n (%) | N=48 160 Events/100 PY (95% CI) n (%) | N=87 838 Events/100 PY (95% CI) n (%) | N=408 415 Events/100 PY (95% CI) n (%) | |
| MACE | 1.89 (1.87–1.91) | 2.58 (2.54–2.61) | 2.70 (2.65–2.76) | 3.34 (3.26–3.43) | 2.54 (2.49–2.60) | 1.54 (1.53–1.56) |
| 43 428 (6.9) | 19 859 (9.1) | 10 542 (9.5) | 5539 (11.5) | 7853 (8.9) | 23 569 (5.8) | |
| Myocardial infarction | 1.11 (1.10–1.13) | 1.54 (1.52–1.57) | 1.89 (1.84–1.93) | 1.37 (1.31–1.42) | 1.53 (1.49–1.58) | 0.90 (0.88–0.91) |
| 25 918 (4.1) | 12 088 (5.6) | 7443 (6.7) | 2337 (4.9) | 4810 (5.5) | 13 830 (3.4) | |
| Ischemic stroke | 0.95 (0.93–0.96) | 1.21 (1.18–1.23) | 0.95 (0.92–0.98) | 2.36 (2.28–2.43) | 1.15 (1.12–1.19) | 0.81 (0.80–0.83) |
| 22 051 (3.5) | 9487 (4.4) | 3800 (3.4) | 3975 (8.3) | 3631 (4.1) | 12 564 (3.1) | |
| Cardiovascular death | 0.17 (0.17–0.18) | 0.25 (0.24–0.26) | 0.23 (0.22–0.25) | 0.33 (0.31–0.36) | 0.28 (0.26–0.30) | 0.14 (0.13–0.14) |
| 4123 (0.7) | 1985 (0.9) | 949 (0.9) | 580 (1.2) | 904 (1.0) | 2138 (0.5) |
CAD indicates coronary artery disease; CVD, cerebrovascular disease; MACE, major adverse cardiovascular event; PAD, peripheral artery disease; PY, person‐years.
a
These cohorts overlap each other.