Table 1.
Patient Characteristics (n=1645)
| Total (n=1645) | Low PRS (n=329) | Average PRS (n=987) | High PRS (n=329) | P Value | |
|---|---|---|---|---|---|
| Age, y | 57 (50–64) | 58 (51–64) | 57 (51–64) | 56 (49–63) | 0.022 |
| Male sex | 799 (49%) | 170 (52%) | 518 (52%) | 158 (48%) | 0.37 |
| Family history of CAD <60 y in first‐degree relative | 601 (37%) | 93 (28%) | 358 (36%) | 150 (46%) | <0.001 |
| Antihypertensive treatment | 411 (25%) | 83 (25%) | 249 (25%) | 79 (24%) | 0.90 |
| Lipid‐lowering treatment | 384 (24%) | 59 (18%) | 236 (24%) | 89 (28%) | 0.015 |
| Diabetes mellitus | 94 (6%) | 15 (5%) | 59 (6%) | 20 (6%) | 0.60 |
| Active smoking | 266 (16%) | 57 (17%) | 156 (16%) | 53 (16%) | 0.82 |
| Symptoms | |||||
| Typical chest pain | 89 (27%) | 72 (22%) | 291 (30%) | 89 (27%) | 0.005 |
| Atypical chest pain | 550 (34%) | 115 (35%) | 306 (31%) | 129 (39%) | |
| Nonanginal chest pain | 293 (18%) | 63 (19%) | 189 (19%) | 41 (13%) | |
| Dyspnea | 340 (21%) | 76 (23%) | 195 (20%) | 69 (21%) | |
| BMI, kg/m2 | 26.3 (23.8–29.4) | 26.9 (24.3–29.6) | 26.2 (23.7–29.3) | 26.5 (23.7–29.5) | 0.21 |
| Total cholesterol, mmol/L | 5.3 (4.7‐6.0) | 5.2 (4.6–5.9) | 5.3 (4.7–6.1) | 5.3 (4.6–6.2) | 0.17 |
| HDL cholesterol, mmol/L | 1.4 (1.1–1.7) | 1.4 (1.2–1.7) | 1.4 (1.1–1.7) | 1.4 (1.1–1.7) | 0.14 |
| LDL cholesterol, mmol/L | 3.3 (2.6–3.9) | 3.1 (2.6–3.8) | 3.3 (2.7–3.9) | 3.4 (2.6–4.0) | 0.055 |
| Triglycerides, mmol/L | 1.3 (1.0–2.0) | 1.3 (0.9–1.9) | 1.3 (1.0–2.0) | 1.4 (1.0–2.2) | 0.049 |
| Creatinine, μmol/L | 74 (65–85) | 75 (65–85) | 74 (65–85) | 75 (66–85) | 0.67 |
Data are presented as number (percentage) or median (interquartile range). Family history was missing in 6 patients, lipid‐lowering treatment was missing in 28 patients, diabetes mellitus was missing in 6 patients, smoking was missing in 7 patients, symptoms was missing in 10 patients, BMI was missing in 9 patients, total cholesterol was missing in 100 patients, HDL cholesterol was missing in 97 patients, LDL cholesterol was missing in 105 patients, triglycerides was missing in 109 patients, and creatinine was missing in 14 patients. BMI indicates body mass index; CAD, coronary artery disease; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; PRS, polygenic risk score.