. 2020 Jan 25;9(3):e014795. doi: 10.1161/JAHA.119.014795

Table 2.

Association of the PRS With Plaque Burden (n=1645 patients)

	Coronary Plaque Burden Median (25–75th Percentile) [1–99th Percentile]			Model 1 Effect Size (95% CI, P Value)	Model 2 Effect Size (95% CI, P Value)
	Low PRS (n=329)	Average PRS (n=987)	High PRS (n=329)	Model 1 Effect Size (95% CI, P Value)	Model 2 Effect Size (95% CI, P Value)
CACS	0 (0–21) [0–841]	0 (0–85) [0–2565]	18 (0–178) [0–2122]	+81% (+63% to +101%, P=2.0e‐27)	+78% (+60% to +98%, P=4.1e‐26)
Segment stenosis score	0 (0 to 1) [0 to 19]	1 (0 to 4) [0 to 25]	2 (0–7) [0–26]	+29% (+23% to +34%, P=1.5e‐30)	+16% (+11% to +21%, P=2.4e‐29)

The effect size corresponds to the change in % in the geometric mean of the variable per SD increase in the PRS. Model 1 was adjusted for age, sex, the first 4 principal components of ancestry, as well as an interaction term between age and sex. Model 2 was further adjusted for antihypertensive treatment, lipid‐lowering treatment, body mass index, symptoms, and active smoking. CACS indicates coronary artery calcium score; PRS, polygenic risk score.