Table 1.
Baseline Characteristics in Concordant and Discordant Groups by Medians: The ARIC Study
| Overall Population | Four Lipids Less Than Median | Four Lipids Greater Than or Equal to Median | |||||
|---|---|---|---|---|---|---|---|
| hsCRP < Median | hsCRP ≥ Median | P Value | hsCRP < Median | hsCRP ≥ Median | P Value | ||
| Age, y | 62 (58–67) | 62 (57–67) | 62 (58–67) | 0.72 | 62.5 (58–67) | 62 (58–67) | 0.73 |
| Female, n (%) | 5765 (59.1) | 932 (56.1) | 1138 (78.0) | <0.0001 | 611 (41.9) | 1021 (63.1) | <0.0001 |
| Race/center, n (%) | <0.0001 | <0.0001 | |||||
|
Minneapolis, MN, Whites |
2713 (28.0) | 479 (29.1) | 335 (23.1) | 455 (31.4) | 410 (25.5) | ||
| Washington County, MD, Whites | 2658 (27.5) | 406 (24.7) | 313 (21.6) | 449 (31.0) | 512 (31.8) | ||
| Forsyth County, NC, Whites | 2180 (22.5) | 408 (24.8) | 324 (22.4) | 339 (23.4) | 335 (20.8) | ||
| Forsyth County, NC, Blacks | 217 (2.2) | 39 (2.4) | 55 (3.8) | 15 (1.0) | 30 (1.9) | ||
| Jackson, MS, Blacks | 1916 (19.8) | 315 (19.1) | 420 (29.0) | 189 (13.1) | 324 (20.1) | ||
| Body mass index, kg/m2 | 28.0 (24.9–31.6) | 25.5 (22.8–28.4) | 28.5 (24.8–33.4) | <0.001 | 27.6 (25.1–30.4) | 30.2 (27.1–34.2) | <0.0001 |
| LDL‐C, mg/dL | 123.6 (103.3–145.4) | 97.8 (84.0–109.0) | 97.4 (82.8–108.4) | 0.29 | 152.6 (139.1–168.4) | 151.9 (139.4–169.5) | 0.81 |
| Non–HDL‐C, mg/dL | 149 (126–173) | 116 (102–128) | 118 (103–130) | 0.06 | 182 (167–200) | 184 (169–204) | 0.035 |
| TC/HDL‐C | 4.2 (3.3–5.2) | 3.0 (2.5–3.5) | 3.1 (2.6–3.6) | 0.06 | 5.4 (4.8–6.1) | 5.6 (4.9–6.4) | 0.0001 |
| Apolipoprotein B, mg/dL | 98.1 (82.8–113.7) | 78.2 (69.8–85.8) | 79.6 (70.6–87.6) | 0.05 | 117.3 (108.6–129.9) | 119.6 (109.8–132.5) | 0.001 |
| HDL‐C, mg/dL | 48 (39–60) | 58 (48–70) | 57 (47–69) | 0.12 | 42 (36–47) | 41 (35–46) | 0.001 |
| hsCRP, mg/L | 2.4 (1.1–5.4) | 0.9 (0.5–1.5) | 5.7 (3.7–8.9) | <0.0001 | 1.2 (0.8–1.7) | 5.3 (3.7–8.4) | <0.0001 |
| Lipid‐lowering medication use, n (%) | 1104 (11.4) | 138 (8.3) | 90 (6.2) | 0.022 | 133 (9.1) | 125 (7.8) | 0.171 |
| Current smoker, n (%) | 1403 (14.5) | 233 (14.1) | 218 (15.0) | 0.471 | 161 (11.1) | 311 (19.2) | <0.0001 |
| Systolic blood pressure, mm Hg | 125 (114–138) | 122 (111–135) | 126 (114–140) | <0.0001 | 124 (113–137) | 128 (117–141) | <0.0001 |
| Antihypertensive medications, n (%) | 3866 (39.7) | 598 (36.2) | 744 (51.2) | <0.0001 | 589 (40.5) | 838 (51.9) | <0.0001 |
| Diabetes mellitus, n (%) | 1495 (15.4) | 151 (9.2) | 211 (14.6) | <0.0001 | 186 (12.8) | 375 (23.2) | <0.0001 |
| 10‐y ASCVD risk | 8.0 (3.3–14.9) | 6.0 (2.3–11.9) | 5.8 (2.3–11.6) | 0.8966 | 10.5 (5.7–17.5) | 9.7 (4.1–18.5) | 0.0742 |
Medians: LDL‐C: 123 mg/dL, non–HDL‐C: 149 mg/dL, apolipoprotein B: 98 mg/dL, TC/HDL: 4.2, HDL‐C: 40 mg/dL, hsCRP: 2.4 mg/L. Continuous variables are reported as median (25th–75th percentile). Medians and means were compared using Kruskal‐Wallis and chi‐squared test, respectively. International System of Units conversion factors: To convert total, LDL‐C, and HDL‐C to mmol/L, multiple by 0.0249. To convert triglycerides to mmol/L, multiply by 0.0113. ARIC indicates Atherosclerosis Risk in Communities; ASCVD, atherosclerotic cardiovascular disease; HDL‐C, high‐density lipoprotein cholesterol; hsCRP, high‐sensitivity C‐reactive protein; LDL‐C, low‐density lipoprotein cholesterol; TC, total cholesterol.