Table 2.

Hazard Ratios (95% CI) for ASCVD Events Across Concordant/Discordant Groups by Medians: The ARIC Study

Lipid Target Groups	hsCRP	n ASCVD Events/n Individuals	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Model 3 HR (95% CI)	Model 4 HR (95% CI)
Triple lipids < median	< median	237/2060	REF	REF	REF	REF
(n=3938)	≥ median	290/1878	1.57 (1.31–1.88)	1.46 (1.19–1.78)	1.42 (1.16–1.74)	1.42 (1.16–1.73)
Triple lipids ≥ median	< median	315/1954	REF	REF	REF	REF
(n=4064)	≥ median	442/2110	1.56 (1.34–1.81)	1.33 (1.13–1.57)	1.32 (1.12–1.56)	1.31 (1.11–1.55)
Quadruple lipids < median	< median	171/1660	REF	REF	REF	N/A
(n=3120)	≥ median	207/1460	1.62 (1.31–2.01)	1.60 (1.26–2.02)	1.56 (1.23–1.98)	N/A
Quadruple lipids ≥ median	< median	257/1460	REF	REF	REF	N/A
(n=3079)	≥ median	362/1619	1.52 (1.29–1.79)	1.30 (1.08–1.56)	1.29 (1.08–1.55)	N/A

hsCRP less than median groups are reference. Triple lipids: LDL‐C + non–HDL‐C + apolipoprotein B. Quadruple lipids: LDL‐C + non–HDL‐C + apolipoprotein B + TC/HDL‐C. Medians: LDL‐C: 123 mg/dL, non–HDL‐C: 149 mg/dL, apolipoprotein B: 98 mg/dL, TC/HDL: 4.2, HDL‐C: 40 mg/dL, hsCRP: 2.4 mg/L. Model 1: adjusted for age, sex, race/center. Model 2: Model 1 + physical activity + smoking status + body mass index + systolic blood pressure + treatment for hypertension + diabetes mellitus + lipid‐lowering medication use.

Model 3: Model 2 + log‐triglycerides. Model 4: Model 3 + log‐HDL‐C. International System of Units conversion factors: To convert total, LDL‐C, and HDL‐C to mmol/L, multiply by 0.0249. To convert triglycerides to mmol/L, multiply by 0.0113. ARIC indicates Atherosclerosis Risk in Communities; ASCVD, atherosclerotic cardiovascular disease; HDL‐C, high‐density lipoprotein cholesterol; HR, hazard ratio; hsCRP, high‐sensitivity C‐reactive protein; LDL‐C, low‐density lipoprotein cholesterol; N/A indicates not applicable; TC, total cholesterol.