Table 3.
Hazard Ratios (95% CI) for ASCVD Events Across Concordant/Discordant Groups by Medians, Grouped Using the Pooled Cohort Equation Risk Score: The ARIC Study
| Lipid Target Groups | hsCRP | Low Risk (<7.5%) | High Risk (≥7.5%) | ||
|---|---|---|---|---|---|
| ASCVD Events, n/Individuals, n | HR (95% CI) | ASCVD Events, n/Individuals, n | HR (95% CI) | ||
| Triple lipids < median | < median | 80/1091 | REF | 154/948 | REF |
| (n=3938) | ≥ median | 125/1010 | 1.79 (1.35–2.37) | 162/851 | 1.27 (1.02–1.59) |
| Triple lipids ≥ median | < median | 75/779 | REF | 238/1162 | REF |
| (n=4064) | ≥ median | 134/931 | 1.57 (1.18–2.08) | 304/1169 | 1.42 (1.20–1.69) |
| Quadruple lipids < median | < median | 65/955 | REF | 104/688 | REF |
| (n=3120) | ≥ median | 96/857 | 1.73 (1.26–2.37) | 110/591 | 1.35 (1.03–1.77) |
| Quadruple lipids ≥ median | < median | 56/507 | REF | 199/942 | REF |
| (n=3079) | ≥ median | 101/651 | 1.47 (1.06–2.04) | 258/962 | 1.42 (1.18–1.71) |
hsCRP <median groups are reference. Triple lipids: LDL‐C + non–HDL‐C + apolipoprotein B. Quadruple lipids: LDL‐C + non–HDL‐C + apolipoprotein B + TC/HDL‐C. Medians: LDL‐C: 123 mg/dL, non–HDL‐C: 149 mg/dL, apolipoprotein B: 98 mg/dL, TC/HDL: 4.2, HDL‐C: 40 mg/dL, hsCRP: 2.4 mg/L. Models adjusted for lipid‐lowering medication use. International System of Units conversion factors: To convert total, LDL‐C, and HDL‐C to mmol/L, multiply by 0.0249. To convert triglycerides to mmol/L, multiply by 0.0113. ARIC indicates Atherosclerosis Risk in Communities; ASCVD, atherosclerotic cardiovascular disease; HDL‐C, high‐density lipoprotein cholesterol; HR, hazard ratio; hsCRP, high‐sensitivity C‐reactive protein; LDL‐C, low‐density lipoprotein cholesterol; N/A indicates not applicable; TC, total cholesterol.