Table 4.
Homocysteine‐Related Odds Ratios for Moderate‐to‐Severe Progression of Calcification in Coronary Arteries and the Descending Thoracic Aortaa, b
| Calcification Progression | Homocysteine Tertile | Hcy | ||
|---|---|---|---|---|
| 1 | 2 | 3 | >12 μmol/L | |
| CAC progression ratec, d | ||||
| 100>ΔCAC >0/y | ref |
1.13 (0.98–1.30) 0.10 |
1.26 (1.07–1.48) 0.007e |
1.43 (1.16–1.75) <0.001e |
| ΔCAC ≥100/y | ref |
1.33 (0.94–1.89) 0.11 |
2.18 (1.53–3.10) <0.001e |
2.21 (1.60–3.04) <0.001e |
| DTAC progression rated, f | ||||
| 100>ΔDTAC >0/y | ref |
1.04 (0.87–1.26) 0.66 |
1.05 (0.86–1.29) 0.63 |
1.19 (0.96–1.47) 0.12 |
| ΔDTAC ≥100/y | ref |
1.64 (1.20–2.24) 0.002∥ |
1.63 (1.16–2.27) 0.004e |
1.42 (1.06–1.92) 0.02e |
CAC indicates coronary artery calcification; DTAC, descending thoracic aorta calcification; Hcy, homocysteine; ref, reference group.
Multinomial logistic regression adjusted for age, race, sex, education, clinic site, body mass index, hypertension, diabetes mellitus, cigarette smoking, total cholesterol, high‐density lipoprotein cholesterol, creatinine‐based estimated glomerular filtration rate (eGFRcr), statin use, and C‐reactive protein. Individuals with missing covariate data were excluded (n=61).
Respective analyses include participants with baseline measurements and at least 1 follow‐up measurement of CAC (n=5992) and DTAC (n=5811).
CAC progression rate, cases: 100>ΔCAC >0/year (3366 cases) or ΔCAC >100/year (408 cases).
Data shown are odds ratios, 95% CIs and P values.
Data with significant P values.
DTAC progression rate, cases: 100>ΔDTAC >0/year (1171 cases) or ΔDTAC >100/year (444 cases).