Table 1.
Baseline characteristics and echocardiographic findings in patients with DNMT3A/TET2 and without DNMT3A/TET2 CHIP-driver mutations
| Total cohort (n = 279) | DNMT3A/TET2 (n = 93) | No-DNMT3A/TET2 (n = 186) | P-value | |
|---|---|---|---|---|
| Age (years) (n = 279) | 83.0 (79.3–86.1) | 83.2 (80.1–86.7) (n = 93) | 82.9 (79.1–85.8) (n = 186) | 0.179 |
| Sex (female) (%) (n = 279) | 42.7% (n = 119) | 51.6% (n = 48) | 38.2% (n = 71) | 0.032 |
| BMI (kg/m2) (n = 279) | 26.2 (23.4–29.4) | 25.5 (22.7–29.4) (n = 93) | 26.5 (23.9–29.4) (n = 186) | 0.147 |
| Hypertension (%) (n = 279) | 88.2% (n = 246) | 91.4% (n = 85) | 86.5% (n = 161) | 0.238 |
| Diabetes (%) (n = 279) | 31.2% (n = 87) | 30.1% (n = 28) | 31.7% (n = 59) | 0.784 |
| On insulin (%) (n = 279) | 9.3% (n = 26) | 10.7% (n = 10) | 8.6% (n = 16) | 0.560 |
| Previous myocardial infarction (%) (n = 279) | 16.5% (n = 46) | 17.2% (n = 16) | 16.1% (n = 30) | 0.820 |
| Previous PCI (%) (n = 279) | 40.9% (n = 114) | 38.7% (n = 36) | 41.9% (n = 78) | 0.605 |
| Previous CABG (%) (n = 279) | 9.3% (n = 26) | 10.7% (n = 10) | 8.6% (n = 16) | 0.560 |
| Previous stroke (%) (n = 279) | 15.4% (n = 43) | 19.3% (n = 18) | 13.4% (n = 25) | 0.197 |
| Previous TIA (%) (n = 279) | 3.6% (n = 10) | 3.2% (n = 3) | 3.8% (n = 7) | 1.0 |
| Carotid artery disease (%) (n = 279) | 18.3% (n = 51) | 17.2% (n = 16) | 18.8% (n = 35) | 0.742 |
| Peripheral artery disease (%) (n = 279) | 11.5% (n = 32) | 10.7% (n = 10) | 11.8% (n = 22) | 0.790 |
| COPD (%) (n = 279) | 19.7% (n = 55) | 18.3% (n = 17) | 20.4% (n = 38) | 0.670 |
| Atrial fibrillation (%) (n = 279) | 47.3% (n = 132) | 50.5% (n = 47) | 45.7% (n = 85) | 0.445 |
| NYHA III (n = 279) | 68.8% (n = 192) | 72.0% (n = 67) | 67.2% (n = 125) | 0.411 |
| NYHA IV (n = 279) | 12.2% (n = 34) | 15.0% (n = 14) | 10.7% (n = 20) | 0.301 |
| LVEF (n = 279) | 60 (50–60) | 60 (45–60) (n = 93) | 60 (50–60) (n = 186) | 0.237 |
| Pmean (mmHg) (n = 260) | 43 (32–53) | 41 (30–53) (n = 88) | 45 (34–53) (n = 172) | 0.171 |
| Mitral valve insufficiency (>II) (n = 274) | 7.6% (n = 21) | 8.7% (n = 8) (n = 92) | 7.1% (n = 13) (n = 182) | 0.648 |
Continuous variables are shown as mean (SD) and median (interquartile range). Categorical variables are shown as frequency (%). Statistically significant difference is shown in bold.
BMI, body mass index; CABG, coronary artery bypass graft; COPD, chronic obstructive pulmonary disease; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; Pmean, mean transvalvular pressure gradient; PCI, percutaneous coronary intervention; TIA, transient ischaemic attack.