Table 1.
patient characteristics and demographics of eligible studies
| Author (year of publication) | Number of patients (n) | Subgroups | Inclusion time frame | Mean patient age (years) | Mean lesion-size (cm) | Curative resection rate | Reductive resection rate | Other treatmenta | Safety margin | Morbidity/Mortalityb | Recurrence rate | Overall survival (%, years of follow-up) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kadry et al. (2005) | 113 | Gr A: complete resection Gr. B: reductive surgery Gr C: BZM alone |
1976 - 2003 | 52 | NR | 64.1% | 21.2% | 40.7% | NR | NR | NR | NR |
| Buttenschoen et al. (2009) | 36 | Gr. A: 1982-1999 Gr B: 2000-2006 |
Gr. A: 1982-1999 Gr. B: 2000-2006 |
NR | NR | Gr A: 21% Gr B: 87% |
Gr A: 79% Gr B: 14% |
0% | Gr. B: 20 mm | Morbidity: 15% Hospital lethality: 3% |
Curative resection: 11% (2/18) | Curative resection: 100% Reductive surgery: 50% |
| Kawamura et al. (2011) | 188 | Gr A: complete resection Gr. B: reductive surgery Gr. C: drainage or laparotomy |
1984-2009 | Gr. A : 53.1 Gr. B : 51.6 Gr. C : 60.6 |
Gr A : 5.1 Gr B : 9.3 Gr C : 15 |
63.5% | 33.5% | 3% | NR | Mortality: 4.2% | Gr. A: 3.5% (10y), 5.6% (15y, 20y) Gr. B: 12.9% (10y), 28.4% (15y), 38.6 % (20y) Gr.C : 50.0% (10y), 66.7% (15y) |
Gr A: 98.9% (10-15-20y) Gr B: 97.1% (10y), 92.8% (15y), 61.9% (20y). Gr C : 50.0% (10y), 33.3% (15y) |
| Joliat et al. (2015) | 59 | No subgroups | 1992-2013 | 60 | 5.5 | 71% | 29% | 0% | NR | Complication: 36% (n=21) Dindo I-II: 25% (n=15) Dindo III-IV: 9% (n=5) Dindo V: 2% (n=1) Mortality: 3% |
Complete resection: 2% (n=1) Reductive surgery: 41% (n=7) |
97% |
| Du et al. (2016) | 144 | Gr. A: complete resection Gr. B: reductive surgery |
2004-2015 | 38.4 | Gr A : 8.1 Gr B: 12.5 | 58.3% | 41.6% | 0% | NR | Complication: 10.4% Dindo I-II: 5.5% Dindo III-IV: 2.7% Dindo V: 2.05% |
NR | NR |
| Hillenbrand et al. (2017) | 92 | No subgroups | 1993-2003 | 40.5 | NR | NR | NR | NR | < 1 mm >20 mm | NR | 16% | NR |
| Chen et al. (2018) | 115 | Gr. A: radical resection Gr. B: reductive resection Gr C: liver transplantation |
2004-2016 | 47.8 | NR | 66.9% | 14.7% | 18.4% | NR | NR | NR | Gr. A: 97% Gr. B: 70.6% Gr. C: 81% |
Gr: Group: NR: not reported, BZM: Benzimidazole.
a
Other treatment include BZM only therapy (Kadry et al., 2005), liver transplantation (Chen et al., 2018), drainage or laparotomy (Kawamura et al., 2011).
b
Morbidity and mortality are defined according to the Dindo-Clavien classification (Dindo et al., 2004).